عنوان مقاله [English]
Introduction & Objective: Liver heptokines are influential factors in obesity-related diseases. Both exercise and diet are essential interventions in obesity control. The purpose of this study was to compare the effectiveness of six weeks of aerobic and resistance training during ketogenic diet on fibroblast growth factor 21 (FGF21) and selenoprotein P and blood lipid profile in overweight or obese men.
Methods: Thirty-six overweight and obese male students with a body mass index above 25 kg/m2 were selected voluntarily and available samples. Then they were randomly divided into three groups including aerobic exercise during ketogenic diet (n = 12), resistance training during ketogenic diet (n = 12) and ketogenic diet alone (n = 12). Aerobic exercise consisted of moderate-intensity running for six weeks and three sessions per week. Resistance training consisted of circuit strength training for six weeks and three sessions per week. The ketogenic diet included a restriction of carbohydrate intake less than or equal to 10% of total daily energy intake. Fasting blood samples were taken in pre-test and post-test. Serum levels of FGF21 and selenoprotein P were measured by ELISA and blood lipid profiles including total cholesterol, HDL, and LDL were measured by enzymatic assay. Two-way mixed analysis of variance was used for statistical analysis. Bonferroni post hoc test was used to compare the between-group differences and paired t-test was used for within-group differences.
Results: According to the results of time X group interaction, no significant difference was found between groups in FGF21(p˃0.05), but time was showing a significant difference (p=0.001). All three groups had a significant increase in FGF21 compared to the pretest (p ≤0.05). The selenoprotein P serum level had not indicated a significant between-group difference and compared to the pretest (p˃0.05). Time X group interaction showed no significant differences between groups in lipid profile (p˃0.05). However, within-group results indicated significant decrease in LDL and cholesterol while an increase in HDL in all groups (p ≤0.05).
Conclusion: According to the results, it seems that both aerobic and resistance training during a ketogenic diet as a useful intervention can increase FGF21 and improve lipid profile in overweight and obese people compared to the pre-test. However, not observed differences between the two types of exercise training. Moreover, both aerobic and resistance training during a period of ketogenic diet had no superiority than the ketogenic diet alone in measured heptokines factors and lipid profile.